Australian chemists have developed a potential new antibiotic that could help in the battle against antibiotic resistant bacteria, including the methicillin-resistant Staphylococcus aureus.
“Existing antibiotics target the bacterial cell membranes but this potential new antibiotic operates in a completely different way,” explained Prof Andrew Abell from the University of Adelaide’s School of Chemistry and Physics, who is a senior author of the paper published in the journal Chemical Science.
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“The compound, although at a very early stage of development – it has not yet been tested on an animal model – has the potential to become the first of a new class of antibiotics.”
The compound is a protein inhibitor that binds to an enzyme called biotin protein ligase, stopping its action and interrupting the life cycle of the bacteria.
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“Bacteria quickly build resistance against the known classes of antibiotics and this is causing a significant global health problem,” Prof Abell said. “Preliminary results show that this new class of compound may be effective against a wide range of bacterial diseases, including tuberculosis which has developed a strain resistant to all known antibiotics.”
The scientists used a novel approach called ‘in situ click chemistry’ to develop the new protein inhibitor. “A selection of small molecules is presented to the bacteria in a way so that the target protein enzyme itself builds the inhibiting compound and also binds with it.”
“In a sense the bacteria unwittingly chooses a compound that will stop its growth and assembles it – like building a weapon and using it against itself. We’ve gone a step further to specifically engineer the enzyme so that it builds the best and most potent weapon.”
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“Our results are promising. We’ve made the compounds; we know they bind and inhibit this enzyme and we’ve shown they stop the growth of a range of bacteria in the laboratory. The next critical step will be investigating their efficacy in an animal model,” Prof Abell concluded.
Birth Control Pills
Birth control pills (also called oral contraceptive pills) are a type of female hormonal birth control method, and are very effective at preventing pregnancy.
Wednesday, July 10, 2013
Wednesday, November 7, 2012
The birth control pill and antibiotics
Sunday, December 4, 2011
Wellbutrin 150Mg
Wellbutrin 150 Mg Sr: Many people are ashamed when they have depression, but people should understand that in this condition there is nothing to ashamed of! If one have depression it doesn’t mean he is crazy! This condition is probably one of most common mental disorders, which nowadays affects more than three hundred million people in the world. Remember none of us is immune from this condition, it may occur in any person, independently of the social position, age, nationality or mentality. Experts predict that in ten years depression will be one of the greatest human problems (some psychologists speak about severe forms of depression that people will have in future). People often complain of insomnia, anxiety, stress, fatigue, pains and vague aches, that accompany depression. Sometimes the causes of depression are unrecognized and in this case it is very hard to heal the patient, just by psychological means, that is why antidepressants Wellbutrin 150mg are widely used by professional doctors from all over the world. Experts advise Wellbutrin (Bupropion) 150mg to treat depressive condition. It may help to get rid of such symptoms of depression as feelings of sadness or emptiness, hopelessness, helplessness or feeling guilty. If you have been advised to take antidepressant, buy Wellbutrin (Bupropion) 150 mg online in our pharmacy
Macrobid (Nitrofurantoin) is an antibiotic (Overnight Shipping Antibiotics) drug that effectively treats such infection as urinary tract infection. The medication is administrated orally, it may be taken with or without. If the drug upsets your stomach you may take it with some food. For more information on the drug use ask your doctor or pharmacist. It is very important to be sure that the drug will do no harm to you, consult your healthcare provider or pharmacist to get more detailed information on the drug and be sure that it is right for you, antibiotic Nitrofurantoin has certain limitations and side effects as any other drug has. Speak to your doctor, he/she will indicate the right doses of the drug for you. In case if you have already been recommended to take this antibiotic drug, check it in our online pharmacy. We always offer high quality medications for the lowest price in the web, the quality of offered pills and delivery system will surely satisfy you, even if you are the most particular customer. You shouldn’t close your eyes on the infection you have today, as it may lead you to other, more serious medical conditions if you do not treat it in time. Do not be slow buy Antibiotics online from the convenience of your home and begin the necessary treatment.
Tuesday, April 26, 2011
Protonix and treatment of diseases of the gastrointestinal tract
Protonix is a medication used in medicine for treatment of diseases of the gastrointestinal tract. Typically, Protonix is used in treatment of stomach and duodenal ulcer. Protonix can even be applied in acute ulcer to decrease symptoms of disease and improve the patient’s state. Numerous clinical researches have revealed that Protonix successfully treats gastritis, reduces a number of relapses during ulcer, and prevents pain sensations. The drug is successfully used in many countries around the world because its efficacy has been proved in practice and annually millions prescription are issued.
Protonix is characterized by a strong and fast action treating effectively diseases. The main drug action consists in decrease in hydrochloric acid production, consequently reducing irritants and avoiding relapses of diseases. Also, in decreased gastric juice, microorganism sensitivity to antibiotics is increased. Such action is provided by drug influence on disease causes. Protonix blocks the acid-pump function reducing gastric secretion level and starting the treatment of stomach diseases.
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Protonix is characterized by a strong and fast action treating effectively diseases. The main drug action consists in decrease in hydrochloric acid production, consequently reducing irritants and avoiding relapses of diseases. Also, in decreased gastric juice, microorganism sensitivity to antibiotics is increased. Such action is provided by drug influence on disease causes. Protonix blocks the acid-pump function reducing gastric secretion level and starting the treatment of stomach diseases.
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Monday, October 25, 2010
Acne Treatment - Birth Control Pills And Other Hormone Therapy
Oral contraceptives (OCs) have been available since 1960, and have been modified since then to reduce their risk of side effects. They are the favoured method of contraception by most young couples. Oral contraceptives prevent ovulation and make conditions difficult for a fertilized egg to implant on the uterus wall.
Oral contraceptives can either be made up of progestin alone (called the minipill), or of a combination of synthetic estrogen and progestin. The combination pill has estrogen, which is usually in the form of ethinyl estradiol, or mestranol (only occasionally).
The vast majority of contraceptive pills use ethinyl etradiol as the estrogen, which acts to lower levels of luteinizing hormone (LH) and increase the sex hormone binding globulin (SHBG). This in turn lowers testosterone, thus reducing the drive of the oil glands that are responsible for acne to produce excess oil.
The level of testosterone in women with acne is within the normal range, but the level is lowered in those on OC’s. Some experts believe that the normal range of testosterone for women that is set by laboratories is higher than it should be. If this is true, it could mask the results for some people whose level, although considered to be within the normal range, is actually high for them individually. In such women, their acne improves when their testosterone is lowered by taking the OC pill.
A number of different forms of progestins are used depending on the brand. The progestins can be used at a constant dose throughout the cycle (monophasic), or the daily dose can vary (biphasic or triphasic). Progestins are hormones that have a differing influence on your body, depending on their molecular structure.
Some progestins have effects that can be androgenic (acting like male hormones), while others are anti-androgenic (blocking the production of androgens or blocking androgen receptors, which allow your body to absorb and use the androgen), and some are even estrogenic (estrogen-like). These different actions certainly can influence the side effects as well as the effect on your skin and acne. For treating acne, those pills that produce little or no androgens, or even those that block androgen production (anti-androgens) are best.
By reducing the effect of the androgen hormones on the sebaceous glands, OC's can reduce the amount of oil your glands produce, which means that your pores are less likely to get blocked. Recent studies have shown that some contraceptives are also effective for treating acne.
Many women who have minimal to mild acne and who are also looking to use some form of contraception would find this very useful. As well, women who have moderate to severe acne can consider this as the primary treatment along with topical therapy. It is also considered to be one of two preferred methods of contraception for women, using oral isotretinoin (Accutane®) for treating severe acne. Mini pills may not offer adequate protection for this purpose.
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Oral contraceptives can either be made up of progestin alone (called the minipill), or of a combination of synthetic estrogen and progestin. The combination pill has estrogen, which is usually in the form of ethinyl estradiol, or mestranol (only occasionally).
The vast majority of contraceptive pills use ethinyl etradiol as the estrogen, which acts to lower levels of luteinizing hormone (LH) and increase the sex hormone binding globulin (SHBG). This in turn lowers testosterone, thus reducing the drive of the oil glands that are responsible for acne to produce excess oil.
The level of testosterone in women with acne is within the normal range, but the level is lowered in those on OC’s. Some experts believe that the normal range of testosterone for women that is set by laboratories is higher than it should be. If this is true, it could mask the results for some people whose level, although considered to be within the normal range, is actually high for them individually. In such women, their acne improves when their testosterone is lowered by taking the OC pill.
A number of different forms of progestins are used depending on the brand. The progestins can be used at a constant dose throughout the cycle (monophasic), or the daily dose can vary (biphasic or triphasic). Progestins are hormones that have a differing influence on your body, depending on their molecular structure.
Some progestins have effects that can be androgenic (acting like male hormones), while others are anti-androgenic (blocking the production of androgens or blocking androgen receptors, which allow your body to absorb and use the androgen), and some are even estrogenic (estrogen-like). These different actions certainly can influence the side effects as well as the effect on your skin and acne. For treating acne, those pills that produce little or no androgens, or even those that block androgen production (anti-androgens) are best.
By reducing the effect of the androgen hormones on the sebaceous glands, OC's can reduce the amount of oil your glands produce, which means that your pores are less likely to get blocked. Recent studies have shown that some contraceptives are also effective for treating acne.
Many women who have minimal to mild acne and who are also looking to use some form of contraception would find this very useful. As well, women who have moderate to severe acne can consider this as the primary treatment along with topical therapy. It is also considered to be one of two preferred methods of contraception for women, using oral isotretinoin (Accutane®) for treating severe acne. Mini pills may not offer adequate protection for this purpose.
Buy Carisoprodol Generic Soma
Thursday, August 5, 2010
Yaz Birth Control Pill Information
Yaz birth control pills are combination oral contraceptives (COCs) designed to prevent pregnancy. The birth control pill works by preventing ovulation and making it difficult for sperm to reach the uterus by causing changes in the cervical and uterine lining. Yaz is a combination tablet of drospirenone and ethinyl estradiol.
Yaz Tablets and Risks
Yaz birth control tablets should be taken once daily, at the same time each day. This type of birth control pill has been associated with dangerous health risks and is not recommended for women with the following conditions:
Yaz Inactive White Pills
A Yaz pill pack consists of 24 light pink active tablets and four inert white pills. A normal dose is one pink tablet every day (at the same time) for 24 consecutive days followed by one white pill for the next four days. Women should have their menstrual cycle while taking the inactive white pills.
Yaz Morning After Pill
Women have reported to have taken Yaz as a form of the 'day after pill.' Meaning, they double the dose two days in a row after having unprotected intercourse. According to some reviews, side effects of using Yaz as a morning after treatment may include nausea, upset stomach, vaginal discharge and an irregular menstrual cycle.
Possible Side Effects of Yaz
Yaz birth control pills have been associated with side effects, ranging from minor to severe. As with most birth control methods, minor side effects may include breast tenderness, weight gain, emotional problems, moodiness, change in menstrual cycle, breakthrough bleeding and more.
The side effects that should be of concern, however, include blood clots, pulmonary embolism, deep vein thrombosis, Gallbladder damage, heart attack and stroke. If you are taking Yaz and begin to experience any unusual symptoms, it is important to see your doctor immediately.
Birth Control Pills Similar to Yaz
Makers of Yaz, Bayer HealthCare Pharmaceuticals, also makes Yasmin (generic: Ocella), the only oral contraceptive similar to Yaz. Both pills combine drospirenone and ethinyl estradiol to prevent pregnancy. Because of the similar make-up, Yaz and Yasmin are associated with the same health risks and should be taken with caution.
Yaz Tablets and Risks
Yaz birth control tablets should be taken once daily, at the same time each day. This type of birth control pill has been associated with dangerous health risks and is not recommended for women with the following conditions:
- High blood pressure
- Migraine headaches
- Heart valve disorder
- Kidney or liver problems
- Adrenal gland disorder
- Unusual vaginal bleeding
- Breast, uterine or any form of hormone-dependant cancer
- History of jaundice
- Gallbladder diseases
- Diabetes
- Seizures or epilepsy
- High cholesterol
Yaz Inactive White Pills
A Yaz pill pack consists of 24 light pink active tablets and four inert white pills. A normal dose is one pink tablet every day (at the same time) for 24 consecutive days followed by one white pill for the next four days. Women should have their menstrual cycle while taking the inactive white pills.
Yaz Morning After Pill
Women have reported to have taken Yaz as a form of the 'day after pill.' Meaning, they double the dose two days in a row after having unprotected intercourse. According to some reviews, side effects of using Yaz as a morning after treatment may include nausea, upset stomach, vaginal discharge and an irregular menstrual cycle.
Possible Side Effects of Yaz
Yaz birth control pills have been associated with side effects, ranging from minor to severe. As with most birth control methods, minor side effects may include breast tenderness, weight gain, emotional problems, moodiness, change in menstrual cycle, breakthrough bleeding and more.
The side effects that should be of concern, however, include blood clots, pulmonary embolism, deep vein thrombosis, Gallbladder damage, heart attack and stroke. If you are taking Yaz and begin to experience any unusual symptoms, it is important to see your doctor immediately.
Birth Control Pills Similar to Yaz
Makers of Yaz, Bayer HealthCare Pharmaceuticals, also makes Yasmin (generic: Ocella), the only oral contraceptive similar to Yaz. Both pills combine drospirenone and ethinyl estradiol to prevent pregnancy. Because of the similar make-up, Yaz and Yasmin are associated with the same health risks and should be taken with caution.
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